Below you find the latest publications on PubMed that discuss the FinnDiane cohort. For a complete overview click here
- CONCLUSIONS: This study suggests rare and low-frequency variants and genes associated with SDR in type 1 diabetes, in particular AFAP1L1, SLC30A9, HPS3, PELI1, and CSMD2. However, further validation is required to confirm their roles and mechanisms.
- CONCLUSION: Quantification of circulating JKP proteins using the Joslin OLINK platform discriminates ESKD risk in individuals with diabetes and their response to reno-protective drugs. Use of this multi-purpose precision medicine tool should facilitate studies on the etiology of DKD and enable the development of effective personalized treatment protocols for individuals with DKD.
- CONCLUSIONS: The LL genotype of the HMOX1 GTn repeat and the AA genotype of -413A/T SNP were associated with ischemic cardiac complications and all-cause mortality in men, but not in women. Thus, the HMOX1 genotype may influence the development of cardiovascular complications in individuals with T1D in a sex-dependent manner.
- No abstract
- CONCLUSION: Hypertension during pregnancy is associated with increased risk of cardiovascular events during long-term follow-up in women with T1D, with pre-eclampsia conferring the highest risk. For all-cause mortality, chronic hypertension and pre-eclampsia, but not gestational hypertension, increases the risk of death, yet not independently of diabetic kidney disease.
